| 9/3/2010 | Villanova 24 @ Temple Owls 31 | |
| 9/11/2010 | Villanova 35 @ Lehigh Mountain Hawks 0 | |
| 9/18/2010 | Towson Tigers 7 @ Villanova 43 | † |
| 9/25/2010 | Pennsylvania Quakers 10 @ Villanova 22 | |
| 10/2/2010 | Villanova 24 @ William & Mary Tribe 31 | † |
| 10/16/2010 | Villanova 48 @ Maine Black Bears 18 | † |
| 10/23/2010 | James Madison Dukes 7 @ Villanova 14 | † |
| 10/30/2010 | Richmond Spiders 7 @ Villanova 28 | † |
| 11/6/2010 | Villanova 14 @ Rhode Island Rams 17 | † |
| 11/13/2010 | New Hampshire Wildcats 31 @ Villanova 24 | † |
| 11/20/2010 | Villanova 28 @ Delaware Blue Hens 21 1OT | † |
| 12/4/2010 | Villanova 54 @ Stephen F. Austin Lumberjacks 24 | |
| 12/11/2010 | Villanova 42 @ Appalachian State Mountaineers 24 | |
| 12/17/2010 | Villanova 31 @ Eastern Washington Eagles 41 (FCS Semifinals) |