| 9/4/2010 | St Francis PA Fighting Saints 7 @ Liberty 52 | |
| 9/11/2010 | Liberty 27 @ Ball State Cardinals 23 | |
| 9/18/2010 | Liberty 23 @ Robert Morris Colonials 30 | |
| 9/25/2010 | Liberty 3 @ James Madison Dukes 10 | |
| 10/2/2010 | Savannah State Tigers 14 @ Liberty 52 | |
| 10/9/2010 | Charleston Southern Buccaneers 20 @ Liberty 44 | † |
| 10/16/2010 | Liberty 41 @ VMI Keydets 7 | † |
| 10/30/2010 | Liberty 34 @ Presbyterian Blue Hose 24 | † |
| 11/6/2010 | Gardner-Webb Runnin' Bulldogs 14 @ Liberty 40 | † |
| 11/13/2010 | Liberty 31 @ Coastal Carolina Chanticleers 45 | † |
| 11/20/2010 | Stony Brook Seawolves 28 @ Liberty 54 | † |