| 9/2/2010 | Presbyterian Blue Hose 13 @ Wake Forest 53 | |
| 9/11/2010 | Duke Blue Devils 48 @ Wake Forest 54 | † |
| 9/18/2010 | Wake Forest 24 @ Stanford Cardinal 68 | |
| 9/25/2010 | Wake Forest 0 @ Florida State Seminoles 31 | † |
| 10/2/2010 | Georgia Tech Yellow Jackets 24 @ Wake Forest 20 | † |
| 10/9/2010 | Navy Midshipmen 28 @ Wake Forest 27 | |
| 10/16/2010 | Wake Forest 21 @ Virginia Tech Hokies 52 | † |
| 10/30/2010 | Wake Forest 14 @ Maryland Terrapins 62 | † |
| 11/6/2010 | Boston College Eagles 23 @ Wake Forest 13 | † |
| 11/13/2010 | Wake Forest 3 @ North Carolina State Wolfpack 38 | † |
| 11/20/2010 | Clemson Tigers 30 @ Wake Forest 10 | † |
| 11/27/2010 | Wake Forest 34 @ Vanderbilt Commodores 13 |