| 9/4/2010 | Wisconsin Badgers 41 @ UNLV 21 | |
| 9/11/2010 | UNLV 10 @ Utah Utes 38 | † |
| 9/18/2010 | UNLV 7 @ Idaho Vandals 30 | |
| 9/25/2010 | New Mexico Lobos 10 @ UNLV 45 | † |
| 10/2/2010 | Nevada Wolf Pack 44 @ UNLV 26 | |
| 10/9/2010 | UNLV 10 @ West Virginia Mountaineers 49 | |
| 10/16/2010 | UNLV 10 @ Colorado State Rams 43 | † |
| 10/30/2010 | TCU Horned Frogs 40 @ UNLV 6 | † |
| 11/6/2010 | UNLV 7 @ BYU Cougars 55 | † |
| 11/13/2010 | Wyoming Cowboys 16 @ UNLV 42 | † |
| 11/18/2010 | Air Force Falcons 35 @ UNLV 20 | † |
| 11/27/2010 | UNLV 14 @ San Diego State Aztecs 48 | † |
| 12/4/2010 | UNLV 21 @ Hawaii Warriors 59 |