| 9/11/2010 | UL Monroe 7 vs Arkansas Razorbacks 31 (Little Rock AR) | |
| 9/18/2010 | UL Monroe 20 @ Arkansas State Red Wolves 34 | † |
| 9/25/2010 | Southeastern Louisiana Lions 20 @ UL Monroe 21 | |
| 10/2/2010 | UL Monroe 3 @ Auburn Tigers 52 | |
| 10/9/2010 | Florida Atlantic Owls 17 @ UL Monroe 20 | † |
| 10/16/2010 | UL Monroe 35 @ Western Kentucky Hilltoppers 30 | † |
| 10/23/2010 | UL Monroe 10 @ Middle Tenn State Blue Raiders 38 | † |
| 10/30/2010 | Troy Trojans 14 @ UL Monroe 28 | † |
| 11/6/2010 | UL Monroe 35 @ Florida Intl Golden Panthers 42 2OT | † |
| 11/13/2010 | UL Monroe 0 @ LSU Tigers 51 | |
| 11/20/2010 | North Texas Eagles 37 @ UL Monroe 49 | † |
| 11/27/2010 | UL Lafayette Ragin' Cajuns 23 @ UL Monroe 22 | † |