| 9/2/2010 | Pittsburgh 24 @ Utah Utes 27 1OT | |
| 9/11/2010 | New Hampshire Wildcats 16 @ Pittsburgh 38 | |
| 9/23/2010 | Miami-Florida Hurricanes 31 @ Pittsburgh 3 | |
| 10/2/2010 | Florida Intl Golden Panthers 17 @ Pittsburgh 44 | |
| 10/9/2010 | Pittsburgh 17 @ Notre Dame Fighting Irish 23 | |
| 10/16/2010 | Pittsburgh 45 @ Syracuse Orangemen 14 | † |
| 10/23/2010 | Rutgers Scarlet Knights 21 @ Pittsburgh 41 | † |
| 10/30/2010 | Louisville Cardinals 3 @ Pittsburgh 21 | † |
| 11/11/2010 | Pittsburgh 28 @ Connecticut Huskies 30 | † |
| 11/20/2010 | Pittsburgh 17 @ South Florida Bulls 10 | † |
| 11/26/2010 | West Virginia Mountaineers 35 @ Pittsburgh 10 | † |
| 12/4/2010 | Pittsburgh 28 @ Cincinnati Bearcats 10 | † |
| 1/8/2011 | Pittsburgh 27 vs Kentucky Wildcats 10 (Birmingham - BBVA Compass Bowl) |