| 9/4/2010 | UCLA Bruins 22 @ Kansas State 31 | |
| 9/11/2010 | Missouri State Bears 24 @ Kansas State 48 | |
| 9/18/2010 | Iowa State Cyclones 20 vs Kansas State 27 (Kansas City MO) | † |
| 9/25/2010 | UCF Knights 13 @ Kansas State 17 | |
| 10/7/2010 | Nebraska Cornhuskers 48 @ Kansas State 13 | † |
| 10/14/2010 | Kansas State 59 @ Kansas Jayhawks 7 | † |
| 10/23/2010 | Kansas State 42 @ Baylor Bears 47 | † |
| 10/30/2010 | Oklahoma State Cowboys 24 @ Kansas State 14 | † |
| 11/6/2010 | Texas Longhorns 14 @ Kansas State 39 | † |
| 11/13/2010 | Kansas State 28 @ Missouri Tigers 38 | † |
| 11/20/2010 | Kansas State 36 @ Colorado Buffaloes 44 | † |
| 11/27/2010 | Kansas State 49 @ North Texas Eagles 41 | |
| 12/30/2010 | Kansas State 34 vs Syracuse Orangemen 36 (New York - Pinstripe Bowl) |