11 Jan 2011 5:05pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Alabama | 9-3 |
| L 14-44 at | 9/4/2010 | Penn State (6-5) | 9/11/2010 | W 24-3 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Florida | 8-5 |
| L 14-44 at | 9/4/2010 | Penn State (6-5) | 1/1/2011 | W 37-24 vs |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Illinois | 7-6 |
| L 14-44 at | 9/4/2010 | Penn State (6-5) | 10/9/2010 | W 33-13 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Indiana | 5-7 |
| L 14-44 at | 9/4/2010 | Penn State (5-6) | 11/20/2010 | L 24-41 vs |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Iowa | 8-5 |
| L 14-44 at | 9/4/2010 | Penn State (6-5) | 10/2/2010 | W 24-3 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Kent State | 5-7 |
| L 14-44 at | 9/4/2010 | Penn State (5-6) | 9/18/2010 | L 0-24 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Michigan | 7-6 |
| L 14-44 at | 9/4/2010 | Penn State (5-6) | 10/30/2010 | L 31-41 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Michigan State | 11-2 |
| L 14-44 at | 9/4/2010 | Penn State (6-5) | 11/27/2010 | W 28-22 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Minnesota | 3-9 |
| L 14-44 at | 9/4/2010 | Penn State (5-6) | 10/23/2010 | L 21-33 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Northwestern | 7-6 |
| L 14-44 at | 9/4/2010 | Penn State (5-6) | 11/6/2010 | L 21-35 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Ohio State | 12-1 |
| L 14-44 at | 9/4/2010 | Penn State (6-5) | 11/13/2010 | W 38-14 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Temple | 8-4 |
| L 14-44 at | 9/4/2010 | Penn State (5-6) | 9/25/2010 | L 13-22 at |
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