| 9/6/2009 | Grambling | 34 | vs | S Carolina St | 31 | Orlando FL | |||
| 9/12/2009 | S Carolina St | 24 | @ | Bethune-Cookman | 3 | MEAC | |||
| 9/26/2009 | Winston-Salem St | 10 | @ | S Carolina St | 27 | MEAC | |||
| 10/3/2009 | S Carolina St | 14 | @ | South Carolina | 38 | ||||
| 10/10/2009 | S Carolina St | 37 | @ | Norfolk St | 10 | MEAC | |||
| 10/17/2009 | Florida A&M | 20 | @ | S Carolina St | 35 | MEAC | |||
| 10/24/2009 | S Carolina St | 21 | @ | Hampton | 9 | MEAC | |||
| 10/31/2009 | Delaware St | 10 | @ | S Carolina St | 52 | MEAC | |||
| 11/7/2009 | S Carolina St | 43 | @ | Howard | 13 | MEAC | |||
| 11/14/2009 | Morgan St | 13 | @ | S Carolina St | 37 | MEAC | |||
| 11/21/2009 | NC A&T | 10 | @ | S Carolina St | 28 | MEAC | |||
| 11/28/2009 | S Carolina St | 13 | @ | Appalachian St | 20 | FCS Playoff round 1 |