| 9/5/2009 | Buffalo | 23 | @ | UTEP | 17 | ||||
| 9/12/2009 | Pittsburgh | 54 | @ | Buffalo | 27 | ||||
| 9/19/2009 | Buffalo | 17 | @ | UCF | 23 | ||||
| 9/26/2009 | Buffalo | 13 | @ | Temple | 37 | MAC | |||
| 10/3/2009 | Central Michigan | 20 | @ | Buffalo | 13 | MAC | |||
| 10/10/2009 | Gardner Webb | 3 | @ | Buffalo | 40 | ||||
| 10/17/2009 | Akron | 17 | @ | Buffalo | 21 | MAC | |||
| 10/24/2009 | Buffalo | 31 | @ | Western Michigan | 34 | OT | MAC | ||
| 11/3/2009 | Bowling Green | 30 | @ | Buffalo | 29 | MAC | |||
| 11/10/2009 | Ohio | 27 | @ | Buffalo | 24 | MAC | |||
| 11/18/2009 | Buffalo | 42 | @ | Miami-Ohio | 17 | MAC | |||
| 11/27/2009 | Buffalo | 9 | @ | Kent St | 6 | MAC |