| 9/3/2005 | Appalachian St | 24 | @ | Eastern Kentucky | 16 | ||||
| 9/10/2005 | Appalachian St | 8 | @ | Kansas | 36 | ||||
| 9/17/2005 | Coastal Car | 3 | @ | Appalachian St | 20 | ||||
| 9/24/2005 | Appalachian St | 45 | @ | The Citadel | 13 | SoCon | |||
| 10/8/2005 | Appalachian St | 31 | @ | Furman | 34 | SoCon | |||
| 10/15/2005 | Ga Southern | 7 | @ | Appalachian St | 24 | SoCon | |||
| 10/22/2005 | Appalachian St | 49 | @ | Wofford | 17 | SoCon | |||
| 10/29/2005 | Chattanooga | 25 | @ | Appalachian St | 35 | SoCon | |||
| 11/5/2005 | Appalachian St | 0 | @ | #10 LSU | 24 | ||||
| 11/12/2005 | Western Carolina | 7 | @ | Appalachian St | 35 | SoCon | |||
| 11/19/2005 | Appalachian St | 52 | @ | Elon | 14 | SoCon |