| 9/3/2005 | Ohio | 14 | @ | Northwestern | 38 | ||||
| 9/10/2005 | Northern Illinois | 37 | @ | Northwestern | 38 | ||||
| 9/17/2005 | Northwestern | 21 | @ | Arizona St | 52 | ||||
| 9/24/2005 | #3 Penn State | 34 | @ | Northwestern | 29 | B10 | |||
| 10/8/2005 | #20 Wisconsin | 48 | @ | Northwestern | 51 | B10 | |||
| 10/15/2005 | Northwestern | 34 | @ | Purdue | 29 | B10 | |||
| 10/22/2005 | Northwestern | 49 | @ | Michigan St | 14 | B10 | |||
| 10/29/2005 | #20 Michigan | 38 | @ | Northwestern | 17 | B10 | |||
| 11/5/2005 | #25 Iowa | 27 | @ | Northwestern | 28 | B10 | |||
| 11/12/2005 | Northwestern | 7 | @ | #4 Ohio State | 48 | B10 | |||
| 11/19/2005 | Northwestern | 38 | @ | Illinois | 21 | B10 | |||
| 12/30/2005 | Northwestern | 38 | vs | #17 UCLA | 50 | Sun |