| 9/2/2005 | Indiana | 20 | @ | Central Michigan | 13 | ||||
| 9/10/2005 | Nicholls St | 31 | @ | Indiana | 35 | ||||
| 9/17/2005 | Kentucky | 14 | @ | Indiana | 38 | ||||
| 10/1/2005 | Indiana | 24 | @ | #20 Wisconsin | 41 | B10 | |||
| 10/8/2005 | Illinois | 13 | @ | Indiana | 36 | B10 | |||
| 10/15/2005 | Indiana | 21 | @ | #25 Iowa | 38 | B10 | |||
| 10/22/2005 | #4 Ohio State | 41 | @ | Indiana | 10 | B10 | |||
| 10/29/2005 | Indiana | 13 | @ | Michigan St | 46 | B10 | |||
| 11/5/2005 | Minnesota | 42 | @ | Indiana | 21 | B10 | |||
| 11/12/2005 | Indiana | 14 | @ | #20 Michigan | 41 | B10 | |||
| 11/19/2005 | Purdue | 41 | @ | Indiana | 14 | B10 |